Ontology highlight
ABSTRACT:
SUBMITTER: Cheng Y
PROVIDER: S-EPMC6350936 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Cheng Ying Y Sun Miao M Chen Li L Li Yujing Y Lin Li L Yao Bing B Li Ziyi Z Wang Zhiqin Z Chen Jack J Miao Zhigang Z Xin Ning N Huang Luoxiu L Allen Emily G EG Wu Hao H Xu Xingshun X Jin Peng P
Cell reports 20181201 11
5-hydroxymethylcytosine (5hmC) is enriched in brain and has been recognized as an important DNA modification. However, the roles of 5hmC and its writers, ten-eleven translocation (Tet) proteins, in stress-induced response have yet to be elucidated. Here, we show that chronic restraint stress (CRS) induced depression-like behavior in mice and resulted in a 5hmC reduction in prefrontal cortex (PFC). We found that loss of Tet1 (Tet1 KO) led to resistance to CRS, whereas loss of Tet2 (Tet2 KO) incre ...[more]