Ontology highlight
ABSTRACT:
SUBMITTER: Gerecke C
PROVIDER: S-EPMC8977485 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Gerecke Christian C Egea Rodrigues Caue C Homann Thomas T Kleuser Burkhard B
Frontiers in immunology 20220321
Ten-eleven translocation proteins (TET1-3) are dioxygenases that oxidize 5-methyldeoxycytosine, thus taking part in passive and active demethylation. TETs have shown to be involved in immune cell development, affecting from self-renewal of stem cells and lineage commitment to terminal differentiation. In fact, dysfunction of TET proteins have been vastly associated with both myeloid and lymphoid leukemias. Recently, there has been accumulating evidence suggesting that TETs regulate immune cell f ...[more]