Ontology highlight
ABSTRACT:
SUBMITTER: Park JE
PROVIDER: S-EPMC6350940 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Park Jeoung-Eun JE Majumdar Sirshendu S Brand David D DD Rosloniec Edward F EF Yi Ae-Kyung AK Stuart John M JM Kang Andrew H AH Myers Linda K LK
Clinical immunology (Orlando, Fla.) 20180416
The aim of this study was to understand how Syk affects peripheral T cell function. T cells from Syk<sup>-/-</sup> chimeric mice and DR1 Syk<sup>fl/fl</sup> CD4<sup>cre</sup> conditional mice gave strong CD3-induced Th1, Th2, and Th17 cytokine responses. However, an altered peptide ligand (APL) of human CII (256-276) with two substitutions (F263N, E266D), also called A12, elicited only Th2 cytokine responses from Syk<sup>fl/fl</sup> T cells but not Syk<sup>fl/fl-</sup>CD4<sup>cre</sup> T cells. ...[more]