Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection.
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ABSTRACT:
SUBMITTER: Matty MA
PROVIDER: S-EPMC6351102 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection.
Matty Molly A MA Knudsen Daphne R DR Walton Eric M EM Beerman Rebecca W RW Cronan Mark R MR Pyle Charlie J CJ Hernandez Rafael E RE Tobin David M DM
eLife 20190129
<i>Mycobacterium tuberculosis</i> is the leading worldwide cause of death due to a single infectious agent. Existing anti-tuberculous therapies require long treatments and are complicated by multi-drug-resistant strains. Host-directed therapies have been proposed as an orthogonal approach, but few have moved into clinical trials. Here, we use the zebrafish-<i>Mycobacterium marinum</i> infection model as a whole-animal screening platform to identify FDA-approved, host-directed compounds. We ident ...[more]
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