Ontology highlight
ABSTRACT:
SUBMITTER: Damsky W
PROVIDER: S-EPMC6351852 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
The New England journal of medicine 20181201 26
There is evidence that Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling plays a role in the pathogenesis of sarcoidosis. We treated a patient with cutaneous sarcoidosis with the JAK inhibitor tofacitinib; the patient had not previously had a response to medications and had not received systemic glucocorticoids. This treatment resulted in clinical and histologic remission of her skin disease. Sequencing of RNA and immunohistochemical examination of skin-lesion ...[more]