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Tofacitinib Treatment and Molecular Analysis of Cutaneous Sarcoidosis.


ABSTRACT: There is evidence that Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling plays a role in the pathogenesis of sarcoidosis. We treated a patient with cutaneous sarcoidosis with the JAK inhibitor tofacitinib; the patient had not previously had a response to medications and had not received systemic glucocorticoids. This treatment resulted in clinical and histologic remission of her skin disease. Sequencing of RNA and immunohistochemical examination of skin-lesion samples obtained from the patient before and during therapy and immunohistochemical testing of lesion samples obtained from other patients with cutaneous sarcoidosis support a role for JAK-STAT signaling in cutaneous sarcoidosis. (Funded by the Ranjini and Ajay Poddar Resource Fund for Dermatologic Diseases Research and others.).

SUBMITTER: Damsky W 

PROVIDER: S-EPMC6351852 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Tofacitinib Treatment and Molecular Analysis of Cutaneous Sarcoidosis.

Damsky William W   Thakral Durga D   Emeagwali Nkiruka N   Galan Anjela A   King Brett B  

The New England journal of medicine 20181201 26


There is evidence that Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling plays a role in the pathogenesis of sarcoidosis. We treated a patient with cutaneous sarcoidosis with the JAK inhibitor tofacitinib; the patient had not previously had a response to medications and had not received systemic glucocorticoids. This treatment resulted in clinical and histologic remission of her skin disease. Sequencing of RNA and immunohistochemical examination of skin-lesion  ...[more]

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