Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Evaluation of tofacitinib in cutaneous sarcoidosis [bulk RNA-seq]

ABSTRACT: Sarcoidosis is a multisystem inflammatory disease and no molecularly targeted therapies exist. Here we evaluate the efficacy of tofacitinib (a JAK1/3 inhibitor) in an open-label trial of 10 patients with sarcoidosis and correlate clinical improvement with molecular parameters in blood and skin.

ORGANISM(S): Homo sapiens

PROVIDER: GSE169146 | GEO | 2022/03/30

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Evaluation of tofacitinib in cutaneous sarcoidosis [scRNA-seq]

Project description:Sarcoidosis is a multisystem inflammatory disease and no molecularly targeted therapies exist. Here we evaluate the efficacy of tofacitinib (a JAK1/3 inhibitor) in an open-label trial of 10 patients with sarcoidosis and correlate clinical improvement with molecular parameters in blood and skin.

2022-03-30 | GSE169147 | GEO

Evaluation of tofacitinib in cutaneous sarcoidosis [Olink Explore 1536]

2022-03-30 | GSE169148 | GEO

Evaluation of tofacitinib in cutaneous sarcoidosis

Project description:Evaluation of tofacitinib in cutaneous sarcoidosis

| PRJNA715446 | ENA

Evaluation of tofacitinib in cutaneous sarcoidosis [scRNA-seq]

Project description:Evaluation of tofacitinib in cutaneous sarcoidosis [scRNA-seq]

| PRJNA715583 | ENA

Evaluation of tofacitinib in cutaneous sarcoidosis [Olink Explore 1536]

Project description:Evaluation of tofacitinib in cutaneous sarcoidosis [Olink Explore 1536]

| PRJNA715584 | ENA

Evaluation of tofacitinib in cutaneous sarcoidosis [bulk RNA-seq]

Project description:Evaluation of tofacitinib in cutaneous sarcoidosis [bulk RNA-seq]

| PRJNA715582 | ENA

Evaluation of tofacitinib in cutaneous sarcoidosis

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-03-30 | GSE169149 | GEO

Molecular profiling and gene expression analysis in cutaneous sarcoidosis (CS)

Project description:Cutaneous sarcoidosis skin provides relatively non invasive access to granulomatous sarcoidosis tissue.

2011-10-13 | GSE32887 | GEO

Molecular profiling and gene expression analysis in cutaneous sarcoidosis (CS)

Project description:Cutaneous sarcoidosis skin provides relatively non invasive access to granulomatous sarcoidosis tissue. Twenty participants were enrolled: 15 with active CS and 5 healthy volunteers. Microarray analyses comparing non-LS and healthy volunteer skin with LS showed several thousand genes differentially expressed

2011-10-12 | E-GEOD-32887 | biostudies-arrayexpress

Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment

Project description:The myeloma bone marrow microenvironment drives proliferation of malignant plasma cells and promotes resistance to therapy. Interleukin-6 (IL-6) and downstream JAK/STAT signaling are thought to be central components of these microenvironment-induced phenotypes. In a prior drug repurposing screen, we identified tofacitinib, a pan-JAK inhibitor FDA-approved for rheumatoid arthritis, as an agent that may reverse the tumor-stimulating effects of bone marrow mesenchymal stromal cells.Here, we validated both in vitro, in stromal-responsive human myeloma cell lines, and in vivo, in orthotopic disseminated murine xenograft models of myeloma, that tofacitinib showed both single-agent and combination therapeutic efficacy in myeloma models. Surprisingly, we found that ruxolitinib, an FDA-approved agent targeting JAK1 and JAK2, did not lead to the same anti-myeloma effects. Combination with a novel irreversible JAK3-selective inhibitor also did not rescue ruxolitinib effects. RNA-seq and unbiased phosphoproteomics revealed that marrow stromal cells drive a JAK/STAT-mediated proliferative program in myeloma plasma cells, and tofacitinib reversed the large majority of these pro-growth signals. Taken together, our results suggest that tofacitinib specifically reverses the growth-promoting effects of the tumor microenvironment through blocking an IL-6-mediated signaling axis. As tofacitinib is already FDA-approved, these results can be rapidly translated into potential clinical benefits for myeloma patients.

2018-10-24 | PXD006581 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data