Ontology highlight
ABSTRACT:
SUBMITTER: Condomitti G
PROVIDER: S-EPMC6351853 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Condomitti Giuseppe G Wierda Keimpe D KD Schroeder Anna A Rubio Sara E SE Vennekens Kristel M KM Orlandi Cesare C Martemyanov Kirill A KA Gounko Natalia V NV Savas Jeffrey N JN de Wit Joris J
Neuron 20181002 1
Pyramidal neuron dendrites integrate synaptic input from multiple partners. Different inputs converging on the same dendrite have distinct structural and functional features, but the molecular mechanisms organizing input-specific properties are poorly understood. We identify the orphan receptor GPR158 as a binding partner for the heparan sulfate proteoglycan (HSPG) glypican 4 (GPC4). GPC4 is enriched on hippocampal granule cell axons (mossy fibers), whereas postsynaptic GPR158 is restricted to t ...[more]