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Rabs and axonal regeneration.

ABSTRACT: Membrane trafficking processes are presumably vital for axonal regeneration after injury, but mechanistic understanding in this regard has been sparse. A recent loss-of-function screen had been carried out for factors important for axonal regeneration by cultured cortical neurons and the results suggested that the activity of a number of Rab GTPases might act to restrict axonal regeneration. A loss of Rab27b, in particular, is shown to enhance axonal regeneration in vitro, as well as in C. elegans and mouse central nervous system injury models in vivo. Possible mechanisms underlying this new finding, which has important academic and translational implication, are discussed.

SUBMITTER: Yong CQY

PROVIDER: S-EPMC6352601 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Rabs and axonal regeneration.

Yong Cheryl Qian Ying CQY Tang Bor Luen BL

Neural regeneration research 20190401 4

Membrane trafficking processes are presumably vital for axonal regeneration after injury, but mechanistic understanding in this regard has been sparse. A recent loss-of-function screen had been carried out for factors important for axonal regeneration by cultured cortical neurons and the results suggested that the activity of a number of Rab GTPases might act to restrict axonal regeneration. A loss of Rab27b, in particular, is shown to enhance axonal regeneration in vitro, as well as in C. elega ...[more]

PMID: 30632490

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