Ontology highlight
ABSTRACT:
SUBMITTER: Sumit M
PROVIDER: S-EPMC6352710 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Sumit Madhuresh M Dolatshahi Sepideh S Chu An-Hsiang Adam AA Cote Kaffa K Scarcelli John J JJ Marshall Jeffrey K JK Cornell Richard J RJ Weiss Ron R Lauffenburger Douglas A DA Mulukutla Bhanu Chandra BC Figueroa Bruno B
iScience 20190107
N-linked glycosylation affects the potency, safety, immunogenicity, and pharmacokinetic clearance of several therapeutic proteins including monoclonal antibodies. A robust control strategy is needed to dial in appropriate glycosylation profile during the course of cell culture processes accurately. However, N-glycosylation dynamics remains insufficiently understood owing to the lack of integrative analyses of factors that influence the dynamics, including sugar nucleotide donors, glycosyltransfe ...[more]