Dataset Information

HIV-related excess mortality and age-related comorbidities in patients with HIV aged ?60: a relative survival analysis in the French Dat'AIDS cohort.

ABSTRACT: OBJECTIVE:The objective was to evaluate the association between age-related comorbidities (ARCs) and 5-year HIV-related excess mortality in people living with HIV aged ?60 years. DESIGN:Cohort study using relative survival analysis (Estève's model). SETTING:The French multicentre prospective Dat'AIDS cohort that involves 12 French hospitals. PARTICIPANTS:Inclusion of 1415 HIV-1 infected patients actively followed aged ?60 years on January 2008, with a 5-year follow-up period in the late combination antiretroviral therapy era. RESULTS:Among 1415 patients included, 154 died. By multivariable analysis, factors predictive of 5-year HIV-related excess mortality were non-AIDS-related cancer (adjusted excess HR (aEHR)=2.94; 95% CI 1.32 to 6.57), cardiovascular disease (aEHR=6.00; 95%?CI 2.45 to 14.65), chronic renal disease (aEHR=4.86; 95%?CI 2.24 to 10.53), cirrhosis (aEHR=3.58; 95%?CI 1.25 to 10.28), hepatitis C co-infection (aEHR=3.63; 95%?CI 1.44 to 9.12), body mass index<18.5?kg/m² (aEHR=4.10; 95%?CI 1.61 to 10.48) and having a CD4 cell count ?200/mm3 (aEHR=5.79; 95%?CI 2.28 to 14.69). CONCLUSIONS:ARCs, particularly cardiovascular disease and chronic renal disease, are predictive of HIV-related excess mortality, with an increase in hazard similar to that of CD4 cell count. TRIAL REGISTRATION NUMBER:NCT02898987.

SUBMITTER: Hentzien M

PROVIDER: S-EPMC6352790 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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HIV-related excess mortality and age-related comorbidities in patients with HIV aged ≥60: a relative survival analysis in the French Dat'AIDS cohort.

Hentzien Maxime M Dramé Moustapha M Delpierre Cyrille C Allavena Clotilde C Cabié André A Cuzin Lise L Rey David D Pugliese Pascal P Hédelin Guy G Bani-Sadr Firouzé F

BMJ open 20190125 1

<h4>Objective</h4>The objective was to evaluate the association between age-related comorbidities (ARCs) and 5-year HIV-related excess mortality in people living with HIV aged ≥60 years.<h4>Design</h4>Cohort study using relative survival analysis (Estève's model).<h4>Setting</h4>The French multicentre prospective Dat'AIDS cohort that involves 12 French hospitals.<h4>Participants</h4>Inclusion of 1415 HIV-1 infected patients actively followed aged ≥60 years on January 2008, with a 5-year follow-u ...[more]

PMID: 30782744

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Dataset Information

HIV-related excess mortality and age-related comorbidities in patients with HIV aged ?60: a relative survival analysis in the French Dat'AIDS cohort.

Publications

HIV-related excess mortality and age-related comorbidities in patients with HIV aged ≥60: a relative survival analysis in the French Dat'AIDS cohort.

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