Ontology highlight
ABSTRACT:
SUBMITTER: Ni S
PROVIDER: S-EPMC6352899 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20181015 44
The direct union of primary, secondary, and tertiary carboxylic acids with a chiral glyoxylate-derived sulfinimine provides rapid access into a variety of enantiomerically pure α-amino acids (>85 examples). Characterized by operational simplicity, this radical-based reaction enables the modular assembly of exotic α-amino acids, including both unprecedented structures and those of established industrial value. The described method performs well in high-throughput library synthesis, and has alread ...[more]