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Mild and general conditions for negishi cross-coupling enabled by the use of palladacycle precatalysts.

ABSTRACT: A wide range of biaryls were synthesized by palladium-catalyzed Negishi cross-couplings at ambient temperature or with low catalyst loading. This protocol features the use of a recently reported aminobiphenyl palladacycle precatalyst to generate the catalytically active XPhosPd(0) species. Significantly, a wide range of challenging heterocyclic and polyfluorinated aromatic substrates can be employed to give products in excellent yields.

SUBMITTER: Yang Y

PROVIDER: S-EPMC3697109 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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Mild and general conditions for negishi cross-coupling enabled by the use of palladacycle precatalysts.

Yang Yang Y Oldenhuis Nathan J NJ Buchwald Stephen L SL

Angewandte Chemie (International ed. in English) 20121122 2

A wide range of biaryls were synthesized by palladium-catalyzed Negishi cross-couplings at ambient temperature or with low catalyst loading. This protocol features the use of a recently reported aminobiphenyl palladacycle precatalyst to generate the catalytically active XPhosPd(0) species. Significantly, a wide range of challenging heterocyclic and polyfluorinated aromatic substrates can be employed to give products in excellent yields. ...[more]

PMID: 23172689

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