Ontology highlight
ABSTRACT:
SUBMITTER: Schulz D
PROVIDER: S-EPMC6355177 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Schulz Daniela D Stancev Irene I Sorrentino Antonio A Menevse Ayse-Nur AN Beckhove Philipp P Brockhoff Gero G Hautmann Matthias Günther MG Reichert Torsten Erich TE Bauer Richard Josef RJ Ettl Tobias T
Oncotarget 20190115 5
At present, targeting PD-1/PD-L1 axis for immune checkpoint inhibition has improved treatment of various tumor entities, including head and neck squamous cell carcinoma (HNSCC). However, one part of the patient cohort still shows little improvement or even hyperprogression. We established three radioresistant (RR) and three radiosensitive (RS) HNSCC cell lines. RR cells showed prolonged survival as well as delayed and diminished apoptosis after irradiation with vimentin expression but no E-cadhe ...[more]