Ontology highlight
ABSTRACT:
SUBMITTER: Borgen MA
PROVIDER: S-EPMC6355192 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Borgen Melissa A MA Giles Andrew C AC Wang Dandan D Grill Brock B
eLife 20190118
Synapse formation is comprised of target cell recognition, synapse assembly, and synapse maintenance. Maintaining established synaptic connections is essential for generating functional circuitry and synapse instability is a hallmark of neurodegenerative disease. While many molecules impact synapse formation generally, we know little about molecules that affect synapse maintenance in vivo. Using genetics and developmental time course analysis in <i>C.elegans</i>, we show that the α-tubulin acety ...[more]