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Efficacy of Humanized Cefiderocol Exposures over 72 Hours against a Diverse Group of Gram-Negative Isolates in the Neutropenic Murine Thigh Infection Model.

ABSTRACT: Herein, we evaluated sustainability of humanized exposures of cefiderocol in vivo over 72?h against pathogens with cefiderocol MICs of 0.5 to 16??g/ml in the neutropenic murine thigh model. In Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae displaying MICs of 0.5 to 8??g/ml (n = 11), sustained kill was observed at 72?h among 9 isolates. Postexposure MICs revealed a single 2-dilution increase in one animal compared with controls (1/54 samples, 1.8%) at 72?h. Adaptive resistance during therapy was not observed.

SUBMITTER: Stainton SM

PROVIDER: S-EPMC6355589 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Efficacy of Humanized Cefiderocol Exposures over 72 Hours against a Diverse Group of Gram-Negative Isolates in the Neutropenic Murine Thigh Infection Model.

Stainton Sean M SM Monogue Marguerite L ML Tsuji Masakatsu M Yamano Yoshinori Y Echols Roger R Nicolau David P DP

Antimicrobial agents and chemotherapy 20190129 2

Herein, we evaluated sustainability of humanized exposures of cefiderocol in vivo over 72 h against pathogens with cefiderocol MICs of 0.5 to 16 μg/ml in the neutropenic murine thigh model. In Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae displaying MICs of 0.5 to 8 μg/ml (n = 11), sustained kill was observed at 72 h among 9 isolates. Postexposure MICs revealed a single 2-dilution increase in one animal compared with controls (1/54 sam ...[more]

PMID: 30420477

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