PES1 promotes the occurrence and development of papillary thyroid cancer by upregulating the ER?/ER? protein ratio.

ABSTRACT: PES1, a BRCT domain-containing protein, has been shown to play a role in modulating the balance and ratio between ER? and ER? protein, which is involved in the occurrence and development of breast and ovarian cancer. However, its role in connection with the balance and ratio between ER? and ER? protein in papillary thyroid cancer (PTC) remains unclear. Here, we found that ER? and ER? were co-expressed in human PTC tissues and cells. ER? promoted and ER? inhibited the proliferation, invasion and migration of PTC cells. PES1 modulated the balance between ER? and ER? by elevating the ER? protein level and simultaneously reducing the ER? protein level, then upregulating the ER?/ER? protein ratio and promoting the proliferation, invasion and migration of PTC cells. In PTC tissues, PES1 protein level was positively correlated with the ER? protein level and negatively correlated with the ER? protein level. The PES1 and ER? protein levels were gradually increased and the ER? protein level was decreased by degree in the occurrence and development of PTC. Increased PES1 and ER? protein levels and decreased ER? protein level were correlated with the aggressive behaviors of PTC patients such as large tumor size, extrathyroidal extension (ETE), lymph node metastasis (LNM), high BRAFV600E expression and high TNM stage. It is suggested that PES1 promotes the occurrence and development of PTC by elevating the ER? protein level and reducing the ER? protein level, and then upregulating the ER?/ER? protein ratio.

SUBMITTER: Qiu YB 

PROVIDER: S-EPMC6355968 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature