Ontology highlight
ABSTRACT:
SUBMITTER: Shrivastava AN
PROVIDER: S-EPMC6356061 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
The EMBO journal 20190110 3
Tau assemblies have prion-like properties: they propagate from one neuron to another and amplify by seeding the aggregation of endogenous Tau. Although key in prion-like propagation, the binding of exogenous Tau assemblies to the plasma membrane of naïve neurons is not understood. We report that fibrillar Tau forms clusters at the plasma membrane following lateral diffusion. We found that the fibrils interact with the Na<sup>+</sup>/K<sup>+</sup>-ATPase (NKA) and AMPA receptors. The consequence ...[more]