Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC6356068 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Li Yanjun Y Xue Yanhong Y Xu Xiaojun X Wang Guopeng G Liu Yiqun Y Wu Hao H Li Wenhui W Wang Yueying Y Chen Ziheng Z Zhang Weilin W Zhu Yushan Y Ji Wei W Xu Tao T Liu Lei L Chen Quan Q
The EMBO journal 20181227 3
Both protein quality and mitochondrial quality are vital for the cellular activity, and impaired proteostasis and mitochondrial dysfunction are common etiologies of aging and age-related disorders. Here, we report that the mitochondrial outer membrane protein FUNDC1 interacts with the chaperone HSC70 to promote the mitochondrial translocation of unfolded cytosolic proteins for degradation by LONP1 or for formation of non-aggresomal mitochondrion-associated protein aggregates (MAPAs) upon proteas ...[more]