Dataset Information

Peroxiredoxins in Cancer and Response to Radiation Therapies.

ABSTRACT: Peroxiredoxins have a long-established cellular function as regulators of redox metabolism by catalyzing the reduction of peroxides (e.g., H?O?, lipid peroxides) with high catalytic efficiency. This activity is also critical to the initiation and relay of both phosphorylation and redox signaling in a broad range of pathophysiological contexts. Under normal physiological conditions, peroxiredoxins protect normal cells from oxidative damage that could promote oncogenesis (e.g., environmental stressors). In cancer, higher expression level of peroxiredoxins has been associated with both tumor growth and resistance to radiation therapies. However, this relationship between the expression of peroxiredoxins and the response to radiation is not evident from an analysis of data in The Cancer Genome Atlas (TCGA) or NCI60 panel of cancer cell lines. The focus of this review is to summarize the current experimental knowledge implicating this class of proteins in cancer, and to provide a perspective on the value of targeting peroxiredoxins in the management of cancer. Potential biases in the analysis of the TCGA data with respect to radiation resistance are also highlighted.

SUBMITTER: Forshaw TE

PROVIDER: S-EPMC6356878 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Peroxiredoxins in Cancer and Response to Radiation Therapies.

Forshaw Tom E TE Holmila Reetta R Nelson Kimberly J KJ Lewis Joshua E JE Kemp Melissa L ML Tsang Allen W AW Poole Leslie B LB Lowther W Todd WT Furdui Cristina M CM

Antioxidants (Basel, Switzerland) 20190101 1

Peroxiredoxins have a long-established cellular function as regulators of redox metabolism by catalyzing the reduction of peroxides (e.g., H₂O₂, lipid peroxides) with high catalytic efficiency. This activity is also critical to the initiation and relay of both phosphorylation and redox signaling in a broad range of pathophysiological contexts. Under normal physiological conditions, peroxiredoxins protect normal cells from oxidative damage that could promote oncogenesis (e.g., environmental stres ...[more]

PMID: 30609657

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Project description:We assessed the clinical features and treatment outcome in immunocompetent patients of primary central nervous system lymphoma (PCNSL) by retrospective chart review from 2005–12. Overall survival was analyzed by Kaplan-Meier method. 17 patients met the study criterion (male: female = 11:6). Median age at presentation was 47 years (range 15–74 years). Presenting features included motor impairment in 8(47.06%), raised intracranial tension in 6(35.29%) and seizures in 3(17.65%) patients. Contrast enhanced MRI of brain revealed periventricular lesion, with homogenous contrast enhancement and perilesional edema. Lesions were unifocal in 8(47.06%) and multifocal in 9(52.94%) patients. Stereotactic biopsy and decompression of tumor were performed in 2(11.76%) and 7(41.18%) patients respectively whereas the remaining 8(47.06%) patients were treated on basis of radiology. Histopathology showed diffuse large B cell lymphoma (CD20 + ve) in all 9 patients. Systemic lymphoma workup was negative in all patients. Systemic chemotherapy (median 6 cycles) was given in 14(82.35%) patients. The most common regimen incorporated high dose methotrexate (3gm/m2 IV D1 q3wk) with leucovorin rescue in 12(70.59%) patients- single agent in 10 and in combination in 2 patients. Whole brain radiation (WBRT-median dose 45Gy/25fractions/5weeks) was given in 12(70.59%) patients. After a median follow-up of 21 months (mean 26.24 months), 9(52.94%) patients are in complete response, 2(11.76%) patients are alive with evidence of disease and 6(35.29%) patients expired due to disease progression. The median overall survival was noted to be 34 months (actuarial rate of overall survival at 2 and 3 years- 63.3% and 43.4% respectively). On univariate analysis (Log rank test), KPS (<70 versus ?70) was a significant predictor of overall survival (p = 0.01) whereas age, sex, extent of surgery, treatment modality and choice of chemotherapy had no significant impact upon survival. Stereotactic biopsy followed by high dose single agent methotrexate with WBRT is a reasonable treatment strategy for PCNSL in a developing nation.

Dataset Information

Peroxiredoxins in Cancer and Response to Radiation Therapies.

Publications

Peroxiredoxins in Cancer and Response to Radiation Therapies.

Similar Datasets

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