Ontology highlight
ABSTRACT:
SUBMITTER: Venter WDF
PROVIDER: S-EPMC6358196 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Venter Willem Daniel Francois WDF Kambugu Andrew A Chersich Matthew F MF Becker Stephen S Hill Andrew A Arulappan Natasha N Moorhouse Michelle M Majam Mohammed M Akpomiemie Godspower G Sokhela Simiso S Poongulali Selvamuthu S Feldman Charles C Duncombe Chris C Ripin David H Brown DHB Vos Alinda A Kumarasamy Nagalingeswaran N
Journal of acquired immune deficiency syndromes (1999) 20190201 2
<h4>Background</h4>Reducing doses of antiretroviral drugs, including stavudine (d4T), may lower toxicity, while preserving efficacy. There are substantial concerns about renal and bone toxicities of tenofovir disoproxil fumarate (TDF).<h4>Setting</h4>HIV-1-infected treatment-naive adults in India, South Africa, and Uganda.<h4>Methods</h4>A phase-4, 96-week, randomized, double-blind, noninferiority trial compared d4T 20 mg twice daily and TDF, taken in combination with lamivudine (3TC) and efavir ...[more]