Ontology highlight
ABSTRACT:
SUBMITTER: Hamnett R
PROVIDER: S-EPMC6358603 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Hamnett Ryan R Crosby Priya P Chesham Johanna E JE Hastings Michael H MH
Nature communications 20190201 1
The suprachiasmatic nucleus (SCN) co-ordinates circadian behaviour and physiology in mammals. Its cell-autonomous circadian oscillations pivot around a well characterised transcriptional/translational feedback loop (TTFL), whilst the SCN circuit as a whole is synchronised to solar time by its retinorecipient cells that express and release vasoactive intestinal peptide (VIP). The cell-autonomous and circuit-level mechanisms whereby VIP synchronises the SCN are poorly understood. We show that SCN ...[more]