Ontology highlight
ABSTRACT:
SUBMITTER: Ettouati L
PROVIDER: S-EPMC6359103 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Ettouati Laurent L Senta-Loys Zoé Z Bourgeois Sandrine S Fenet Bernard B Borgne Marc Le ML Fessi Hatem H
Pharmaceutics 20190120 1
Thorough studies of previous analytical stress data of tetrabenazine, a dopamine depleting agent, showed a potential susceptibility to acidic conditions. Hence, the behavior of tetrabenazine acidic solutions was studied by LC-MS and NMR spectroscopy. Reverse-phase LC-MS analysis of tetrabenazine acidic aqueous solutions consistently showed a main lipophilic impurity in a proportion of 15 to 20%. NMR spectroscopy studies did not allow to completely ascertain its structure. However, we hypothesize ...[more]