A PDZ Protein MDA-9/Syntenin: As a Target for Cancer Therapy.
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ABSTRACT:
SUBMITTER: Yu Y
PROVIDER: S-EPMC6360254 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
A PDZ Protein MDA-9/Syntenin: As a Target for Cancer Therapy.
Yu Yongsheng Y Li Shuangdi S Wang Kai K Wan Xiaoping X
Computational and structural biotechnology journal 20190108
Melanoma differentiation-associated gene 9 (MDA-9)/Syntenin is a multidomain PDZ protein and identified as a key oncogene in melanoma initially. This protein contains a unique tandem PDZ domain architecture (PDZ1 and PDZ2 spaced by a 4-amino acid linker), an N-terminal domain (NTD) that is structurally uncharacterized and a short C-terminal domain (CTD). The PDZ1 domain is regarded as the PDZ signaling domain while PDZ2 served as the PDZ superfamily domain. It has various cellular roles by regul ...[more]
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