Ontology highlight
ABSTRACT:
SUBMITTER: Fakhiri J
PROVIDER: S-EPMC6360332 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Fakhiri Julia J Schneider Marc A MA Puschhof Jens J Stanifer Megan M Schildgen Verena V Holderbach Stefan S Voss Yannik Y El Andari Jihad J Schildgen Oliver O Boulant Steeve S Meister Michael M Clevers Hans H Yan Ziying Z Qiu Jianming J Grimm Dirk D
Molecular therapy. Methods & clinical development 20190118
Parvoviruses are highly attractive templates for the engineering of safe, efficient, and specific gene therapy vectors, as best exemplified by adeno-associated virus (AAV). Another candidate that currently garners increasing attention is human bocavirus 1 (HBoV1). Notably, HBoV1 capsids can cross-package recombinant (r)AAV2 genomes, yielding rAAV2/HBoV1 chimeras that specifically transduce polarized human airway epithelia (pHAEs). Here, we largely expanded the repertoire of rAAV/BoV chimeras, by ...[more]