Ontology highlight
ABSTRACT:
SUBMITTER: Jones HG
PROVIDER: S-EPMC6360444 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Acta crystallographica. Section F, Structural biology communications 20190124 Pt 2
Advances in X-ray crystallography have streamlined the process of determining high-resolution three-dimensional macromolecular structures. However, a rate-limiting step in this process continues to be the generation of crystals that are of sufficient size and quality for subsequent diffraction experiments. Here, iterative screen optimization (ISO), a highly automated process in which the precipitant concentrations of each condition in a crystallization screen are modified based on the results of ...[more]