Unknown

Dataset Information

0

Health-related quality of life of patients with inflammatory bowel disease in Singapore.


ABSTRACT:

Background/aims

Inflammatory bowel disease (IBD) is associated with considerable impairment of patients' health-related quality of life (HRQoL). Knowledge of factors that significantly affect IBD patients' HRQoL can contribute to better patient care. However, the HRQoL of IBD patients in non-Western countries are limited. Hence, we assessed the HRQoL of Singaporean IBD patients and identified its determinants.

Methods

A prospective, cross-sectional study was conducted at Singapore General Hospital outpatient IBD Centre. The HRQoL of IBD patients was assessed using the short IBD questionnaire (SIBDQ), Short Form-36 physical and mental component summary (SF-36 PCS/MCS) and EuroQol 5-dimensions 3-levels (EQ-5D-3L) and visual analogue scale (VAS). Independent samples t-test was used to compare HRQoL between Crohn's disease (CD) and ulcerative colitis (UC). Determinants of HRQoL were identified through multiple linear regression.

Results

A total of 195 IBD patients (103 UC, 92 CD) with a mean disease duration of 11.2 years were included. There was no significant difference in HRQoL between patients with UC and CD. Factors that significantly worsened HRQoL were presence of active disease (b=-6.293 [SIBDQ], -9.409 [PCS], -9.743 [MCS], -7.254 [VAS]), corticosteroids use (b=-7.392 [SIBDQ], -10.390 [PCS], -8.827 [MCS]), poor medication adherence (b=-4.049 [SIBDQ], -1.320 [MCS], -8.961 [VAS]), presence of extraintestinal manifestations (b=-13.381 [PCS]), comorbidities (b=-4.531 [PCS]), non-employment (b=-9.738 [MCS], -0.104 [EQ-5D-3L]) and public housing (b=-8.070 [PCS], -9.207 [VAS]).

Conclusions

The HRQoL is impaired in this Asian cohort of IBD. The magnitude of HRQoL impairment was similar in UC and CD. Clinical characteristics were better determinants of patients' HRQoL than socio-demographic factors. Recognizing the factors that impact patients' HRQoL would improve the holistic management of IBD patients.

SUBMITTER: Min Ho PY 

PROVIDER: S-EPMC6361019 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Health-related quality of life of patients with inflammatory bowel disease in Singapore.

Min Ho Prisca Yue PY   Hu Wenjia W   Lee Ying Yun YY   Gao Chuxi C   Tan Yan Zhi YZ   Cheen Hua Heng HH   Wee Hwee Lin HL   Lim Teong Guan TG   Ong Wan Chee WC  

Intestinal research 20181112 1


<h4>Background/aims</h4>Inflammatory bowel disease (IBD) is associated with considerable impairment of patients' health-related quality of life (HRQoL). Knowledge of factors that significantly affect IBD patients' HRQoL can contribute to better patient care. However, the HRQoL of IBD patients in non-Western countries are limited. Hence, we assessed the HRQoL of Singaporean IBD patients and identified its determinants.<h4>Methods</h4>A prospective, cross-sectional study was conducted at Singapore  ...[more]

Similar Datasets

| S-EPMC8237768 | biostudies-literature
| S-EPMC6625837 | biostudies-literature
| S-EPMC5250554 | biostudies-literature
| S-EPMC5149667 | biostudies-other
| S-EPMC10071296 | biostudies-literature
| S-EPMC6652166 | biostudies-literature
| S-EPMC9802169 | biostudies-literature
| S-EPMC10859525 | biostudies-literature
| S-EPMC4670472 | biostudies-literature
| S-EPMC4623582 | biostudies-literature