Ontology highlight
ABSTRACT:
SUBMITTER: Shibata Y
PROVIDER: S-EPMC6361200 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Shibata Yukimasa Y Shibata Yukimasa Y Seki Yoshiyuki Y Nishiwaki Kiyoji K
Biology open 20190117 1
Cell-fate maintenance is important to preserve the variety of cell types that are essential for the formation and function of tissues. We previously showed that the acetylated histone-binding protein BET-1 maintains cell fate by recruiting the histone variant H2A.z. Here, we report that <i>Caenorhabditis elegans</i> TLK-1 and the histone H3 chaperone CAF1 prevent the accumulation of histone variant H3.3. In addition, TLK-1 and CAF1 maintain cell fate by repressing ectopic expression of transcrip ...[more]