Ontology highlight
ABSTRACT:
SUBMITTER: Uprety R
PROVIDER: S-EPMC6361672 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
European journal of medicinal chemistry 20181222
A library-friendly approach to generate new scaffolds is decisive for the development of molecular probes, drug like molecules and preclinical entities. Here, we present the design and synthesis of novel heterocycles with spiro-2,6-dioxopiperazine and spiro-2,6-pyrazine scaffolds through a three-component reaction using various amino acids, ketones, and isocyanides. Screening of select compounds over fifty CNS receptors including G-protein coupled receptors (GPCRs), ion channels, transporters, a ...[more]