Two- vs one-hour glucose tolerance testing: Predicting prediabetes in adolescent girls with obesity.

ABSTRACT: BACKGROUND:During an oral glucose tolerance test (OGTT), morphological features of the glucose curve (monophasic curve, glucose peak >30 minutes and 1-hour glucose ? 155?mg/dL) maybe associated with higher prediabetes risk, but their reproducibility and predictive ability in adolescents with obesity are unknown. METHODS:Nondiabetic adolescent girls with obesity underwent a multiple-sample OGTT at baseline (n?=?93), 6 weeks (n?=?83), and 1 year (n?=?72). Short-term reproducibility (baseline to 6 weeks) and the predictive ability for prediabetes (baseline to 1 year) for each feature were compared with standard fasting and 2-hour OGTT diagnostic criteria. RESULTS:There was fair/moderate short-term reproducibility (?? 30 minutes, 1 hour ?155?mg/dL or a combination of the two criteria were comparable (all P?>?0.05), but the monophasic curve had the lowest ROC-AUC (P? 30 minutes and/or glucose ?155?mg/dL had similar reproducibility and 1-year predictive ability for prediabetes compared with standard OGTT criteria. The shortened 1-hour OGTT may provide diagnostic equivalence for prediabetes risk with the additional advantage of a less time-consuming risk assessment.

SUBMITTER: Kasturi K 

PROVIDER: S-EPMC6361688 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature