Ontology highlight
ABSTRACT:
SUBMITTER: Sharma A
PROVIDER: S-EPMC6361706 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Sharma Amit A Arambula Jonathan F JF Koo Seyoung S Kumar Rajesh R Singh Hardev H Sessler Jonathan L JL Kim Jong Seung JS
Chemical Society reviews 20190201 3
Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically associated with abnormal vasculature, which results in a reduced supply of oxygen and nutrients, as well as impaired delivery of drugs. The hypoxic nature of tumours often leads to the development of localized heterogeneous environments characterized by variable oxygen concentrations, relatively low pH, and increased levels of reactive oxygen species (ROS). The hypoxic heterogeneity promotes tumour invasive ...[more]