Ontology highlight
ABSTRACT:
SUBMITTER: Shortt K
PROVIDER: S-EPMC6362041 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Scientific reports 20190204 1
Acetaminophen (APAP) is a commonly used analgesic responsible for more than half of acute liver failure cases. Identification of previously unknown genetic risk factors would provide mechanistic insights and novel therapeutic targets for APAP-induced liver injury. This study used a genome-wide CRISPR-Cas9 screen to evaluate genes that are protective against, or cause susceptibility to, APAP-induced liver injury. HuH7 human hepatocellular carcinoma cells containing CRISPR-Cas9 gene knockouts were ...[more]