Ontology highlight
ABSTRACT:
SUBMITTER: de Vasconcelos NM
PROVIDER: S-EPMC6362307 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
de Vasconcelos Nathalia M NM Vliegen Gwendolyn G Gonçalves Amanda A De Hert Emilie E Martín-Pérez Rosa R Van Opdenbosch Nina N Jallapally Anvesh A Geiss-Friedlander Ruth R Lambeir Anne-Marie AM Augustyns Koen K Van Der Veken Pieter P De Meester Ingrid I Lamkanfi Mohamed M
Life science alliance 20190204 1
Activating germline mutations in the human inflammasome sensor NLRP1 causes palmoplantar dyskeratosis and susceptibility to Mendelian autoinflammatory diseases. Recent studies have shown that the cytosolic serine dipeptidyl peptidases DPP8 and DPP9 suppress inflammasome activation upstream of NLRP1 and CARD8 in human keratinocytes and peripheral blood mononuclear cells. Moreover, pharmacological inhibition of DPP8/DPP9 protease activity was shown to induce pyroptosis in murine C57BL/6 macrophage ...[more]