DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.
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ABSTRACT:
SUBMITTER: Johnson DC
PROVIDER: S-EPMC6082709 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.
Johnson Darren C DC Taabazuing Cornelius Y CY Okondo Marian C MC Chui Ashley J AJ Rao Sahana D SD Brown Fiona C FC Reed Casie C Peguero Elizabeth E de Stanchina Elisa E Kentsis Alex A Bachovchin Daniel A DA
Nature medicine 20180702 8
Small-molecule inhibitors of the serine dipeptidases DPP8 and DPP9 (DPP8/9) induce a lytic form of cell death called pyroptosis in mouse and human monocytes and macrophages<sup>1,2</sup>. In mouse myeloid cells, Dpp8/9 inhibition activates the inflammasome sensor Nlrp1b, which in turn activates pro-caspase-1 to mediate cell death<sup>3</sup>, but the mechanism of DPP8/9 inhibitor-induced pyroptosis in human myeloid cells is not yet known. Here we show that the CARD-containing protein CARD8 media ...[more]
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