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IL-12 and IL-23/Th17 axis in systemic lupus erythematosus.

ABSTRACT: IMPACT STATEMENT:Our article is focused on emerging pathogenetic pathways in systemic lupus erythematosus (SLE). Notably, IL-12 and IL-23 have been described as emerging cytokines in SLE pathogenesis. We know that IL-23 stimulates Th17 cells to produce IL-17. We try to point out the importance of IL-23/Th17 axis in SLE and to focus on the interaction between this axis and IL-12. Ustekinumab, a fully human IgG1? monoclonal antibody directed towards the p40 shared subunit of IL-12 and IL-23, has been recently investigated in SLE, suggesting a potential novel therapeutic strategy in SLE. To our knowledge, there are no reviews which simultaneously focus on IL-12 an IL-23/Th17 axis in SLE. Thus, we believe our work will be of interest to the readers.

SUBMITTER: Larosa M

PROVIDER: S-EPMC6362534 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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IL-12 and IL-23/Th17 axis in systemic lupus erythematosus.

Larosa Maddalena M Zen Margherita M Gatto Mariele M Jesus Diogo D Zanatta Elisabetta E Iaccarino Luca L Inês Luis L Doria Andrea A

Experimental biology and medicine (Maywood, N.J.) 20190121 1

<h4>Impact statement</h4>Our article is focused on emerging pathogenetic pathways in systemic lupus erythematosus (SLE). Notably, IL-12 and IL-23 have been described as emerging cytokines in SLE pathogenesis. We know that IL-23 stimulates Th17 cells to produce IL-17. We try to point out the importance of IL-23/Th17 axis in SLE and to focus on the interaction between this axis and IL-12. Ustekinumab, a fully human IgG1κ monoclonal antibody directed towards the p40 shared subunit of IL-12 and IL-2 ...[more]

PMID: 30664357

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Analysis of Serum Interleukin (IL)-1? and IL-18 in Systemic Lupus Erythematosus.

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