Ontology highlight
ABSTRACT:
SUBMITTER: Keskeny C
PROVIDER: S-EPMC6362812 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Keskeny Csilla C Raisch Tobias T Sgromo Annamaria A Igreja Cátia C Bhandari Dipankar D Weichenrieder Oliver O Izaurralde Elisa E
Genes & development 20190128 3-4
The multisubunit CCR4-NOT mRNA deadenylase complex plays important roles in the posttranscriptional regulation of gene expression. The NOT4 E3 ubiquitin ligase is a stable component of the CCR4-NOT complex in yeast but does not copurify with the human or <i>Drosophila melanogaster</i> complex. Here we show that the C-terminal regions of human and <i>D. melanogaster</i> NOT4 contain a conserved sequence motif that directly binds the CAF40 subunit of the CCR4-NOT complex (CAF40-binding motif [CBM] ...[more]