Ontology highlight
ABSTRACT:
SUBMITTER: Choi DH
PROVIDER: S-EPMC6362869 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Biochemistry and biophysics reports 20190121
Myostatin (MSTN) is a well-known negative growth factor of muscle mass, and studies have shown that MSTN-inhibition would be a potential strategy to treat muscle atrophy seen in various clinical conditions. Recent studies suggest that MSTN-inhibition induces skeletal muscle hypertrophy through up-regulation of the anabolic Akt/mTOR pathway. Therefore, it was hypothesized that the muscle hypertrophy induced by MSTN-inhibition would be suppressed by the administration of rapamycin (RAP), a mTOR su ...[more]