Ontology highlight
ABSTRACT:
SUBMITTER: Strauss J
PROVIDER: S-EPMC6363002 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Strauss J J Alewine C C Figg W D WD Duffy A A
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20151211 7
Historically, patients diagnosed with metastatic pancreatic cancer have faced a grim prognosis. The survival benefit seen with systemic chemotherapies and even combinations thereof have been disappointing. However, growing data suggest that the microenvironment of pancreatic cancer may be contributing to this poor prognosis. This microenvironment has a dense fibrotic stroma, and is hypoxic and highly immunosuppressive, all of which pose barriers to treatment. Newer strategies looking to disrupt ...[more]