Estrogen related receptor alpha triggers the migration and invasion of endometrial cancer cells via up regulation of TGFB1.

ABSTRACT: Estrogenic signals have been suggested to be important for the tumorigenesis and progression of endometrial cancer (EC) cells. Our present data showed that estrogen related receptor alpha (ERR?), while not ERR? or ERR?, was significantly elevated in EC cells and tissues when compared to their controls. Targeted inhibition of ERR? by siRNA or its inverse agonist XCT-790 can suppress the migration and invasion of EC cells. Both si-ERR? and XCT-790 decreased the expression of transforming growth factor-beta (TGF-?). ERR? can directly bind with the promoter of TGFB1 and then increase its transcription. Further, ERR? was involved in the positive self-feedback loop of TGF-? in EC cells. Targeted inhibition of ERR?/TGF-? can synergistically suppress the in vitro invasion of EC cells. Collectively, our data suggested that ERR? can trigger the cell migration and invasion via increasing the positive self-feedback regulation of TGF-?.

SUBMITTER: Huang X 

PROVIDER: S-EPMC6363028 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature