Ontology highlight
ABSTRACT:
SUBMITTER: Faliti CE
PROVIDER: S-EPMC6363434 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Faliti Caterina E CE Gualtierotti Roberta R Rottoli Elsa E Gerosa Maria M Perruzza Lisa L Romagnani Andrea A Pellegrini Giovanni G De Ponte Conti Benedetta B Rossi Riccardo L RL Idzko Marco M Mazza Emilia M C EMC Bicciato Silvio S Traggiai Elisabetta E Meroni Pier Luigi PL Grassi Fabio F
The Journal of experimental medicine 20190117 2
Altered control of T follicular helper (Tfh) cells can lead to generation of autoantibodies and autoimmune manifestations. Signaling pathways that selectively limit pathogenic responses without affecting the protective function of Tfh cells are unknown. Here we show that the ATP-gated ionotropic P2X7 receptor restricts the expansion of aberrant Tfh cells and the generation of self-reactive antibodies in experimental murine lupus, but its activity is dispensable for the expansion of antigen-speci ...[more]