Ontology highlight
ABSTRACT:
SUBMITTER: Dorner T
PROVIDER: S-EPMC508930 | biostudies-other | 1998 Aug
REPOSITORIES: biostudies-other
The Journal of clinical investigation 19980801 4
To determine whether receptor editing of Vkappa genes was involved in the pathogenesis of systemic lupus erythematosus (SLE), the usage of Vkappa and Jkappa gene elements from individual peripheral CD19(+) B cells obtained from a patient with untreated SLE was examined. No differences in the Vkappa and Jkappa gene usage in the nonproductive gene repertoire of this SLE patient were noted compared with the distribution of genes found in normal adults. However, an increased usage of Jkappa5 segment ...[more]