Ontology highlight
ABSTRACT:
SUBMITTER: Richter F
PROVIDER: S-EPMC6363466 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Richter Frank F Dennerlein Sven S Nikolov Miroslav M Jans Daniel C DC Naumenko Nataliia N Aich Abhishek A MacVicar Thomas T Linden Andreas A Jakobs Stefan S Urlaub Henning H Langer Thomas T Rehling Peter P
The Journal of cell biology 20181231 2
The mitochondrial presequence translocation machinery (TIM23 complex) is conserved between the yeast <i>Saccharomyces cerevisiae</i> and humans; however, functional characterization has been mainly performed in yeast. Here, we define the constituents of the human TIM23 complex using mass spectrometry and identified ROMO1 as a new translocase constituent with an exceptionally short half-life. Analyses of a ROMO1 knockout cell line revealed aberrant inner membrane structure and altered processing ...[more]