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A Supramolecular Vaccine Platform Based on ?-Helical Peptide Nanofibers.

ABSTRACT: A supramolecular peptide vaccine system was designed in which epitope-bearing peptides self-assemble into elongated nanofibers composed almost entirely of alpha-helical structure. The nanofibers were readily internalized by antigen presenting cells and produced robust antibody, CD4+ T-cell, and CD8+ T-cell responses without supplemental adjuvants in mice. Epitopes studied included a cancer B-cell epitope from the epidermal growth factor receptor class III variant (EGFRvIII), the universal CD4+ T-cell epitope PADRE, and the model CD8+ T-cell epitope SIINFEKL, each of which could be incorporated into supramolecular multi-epitope nanofibers in a modular fashion.

SUBMITTER: Wu Y

PROVIDER: S-EPMC6364304 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers.

Wu Yaoying Y Norberg Pamela K PK Reap Elizabeth A EA Congdon Kendra L KL Fries Chelsea N CN Kelly Sean H SH Sampson John H JH Conticello Vincent P VP Collier Joel H JH

ACS biomaterials science & engineering 20170911 12

A supramolecular peptide vaccine system was designed in which epitope-bearing peptides self-assemble into elongated nanofibers composed almost entirely of alpha-helical structure. The nanofibers were readily internalized by antigen presenting cells and produced robust antibody, CD4+ T-cell, and CD8+ T-cell responses without supplemental adjuvants in mice. Epitopes studied included a cancer B-cell epitope from the epidermal growth factor receptor class III variant (EGFRvIII), the universal CD4+ T ...[more]

PMID: 30740520

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