Ontology highlight
ABSTRACT:
SUBMITTER: Geng S
PROVIDER: S-EPMC6365109 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Geng Shuo S Zhang Yao Y Lee Christina C Li Liwu L
Science advances 20190206 2
Nonresolving inflammation perpetuated by innate leukocytes is involved in the pathogenesis of unstable atherosclerosis. However, the role and regulation of neutrophils related to nonresolving inflammation and atherosclerosis are poorly understood. We report herein that chronic subclinical endotoxemia, a risk factor for atherosclerosis, skewed neutrophils into a nonresolving inflammatory state with elevated levels of inflammatory mediators (Dectin-1, MMP9, and LTB4) and reduced levels of homeosta ...[more]