Ontology highlight
ABSTRACT:
SUBMITTER: Arnardottir HH
PROVIDER: S-EPMC4185223 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Arnardottir Hildur H HH Dalli Jesmond J Colas Romain A RA Shinohara Masakazu M Serhan Charles N CN
Journal of immunology (Baltimore, Md. : 1950) 20140912 8
Aging is associated with an overt inflammatory phenotype and physiological decline. Specialized proresolving lipid mediators (SPMs) are endogenous autacoids that actively promote resolution of inflammation. In this study, we investigated resolution of acute inflammation in aging and the roles of SPMs. Using a self-resolving peritonitis and resolution indices coupled with lipid mediator metabololipidomics, we found that aged mice had both delayed resolution and reduced SPMs. The SPM precursor doc ...[more]