Ontology highlight
ABSTRACT:
SUBMITTER: Wirawan M
PROVIDER: S-EPMC6365167 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Wirawan Melissa M Fibriansah Guntur G Marzinek Jan K JK Lim Xin Xiang XX Ng Thiam-Seng TS Sim Adelene Y L AYL Zhang Qian Q Kostyuchenko Victor A VA Shi Jian J Smith Scott A SA Verma Chandra S CS Anand Ganesh G Crowe James E JE Bond Peter J PJ Lok Shee-Mei SM
Structure (London, England : 1993) 20181121 2
Dengue virus (DENV) particles are released from cells in different maturation states. Fully immature DENV (immDENV) is generally non-infectious, but can become infectious when complexed with anti-precursor membrane (prM) protein antibodies. It is unknown how anti-prM antibody-coated particles can undergo membrane fusion since the prM caps the envelope (E) protein fusion loop. Here, we determined cryoelectron microscopy (cryo-EM) maps of the immDENV:anti-prM complex at different pH values, mimick ...[more]