Ontology highlight
ABSTRACT:
SUBMITTER: Malicki S
PROVIDER: S-EPMC6366424 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Malicki Stanislaw S Ksiazek Miroslaw M Majewski Pawel P Pecak Aleksandra A Mydel Piotr P Grudnik Przemyslaw P Dubin Grzegorz G
Journal of enzyme inhibition and medicinal chemistry 20191201 1
Inhibitors of serine proteases are not only extremely useful in the basic research but are also applied extensively in clinical settings. Using Systematic Evolution of Ligands by Exponential Enrichment (SELEX) approach we developed a family of novel, single-stranded DNA aptamers capable of specific trypsin inhibition. Our most potent candidate (T24) and its short version (T59) were thoroughly characterised in terms of efficacy. T24 and T59 efficiently inhibited bovine trypsin with K<sub>i</sub> ...[more]