Ontology highlight
ABSTRACT:
SUBMITTER: Peters EB
PROVIDER: S-EPMC6367050 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Peters Erica B EB Tsihlis Nick D ND Karver Mark R MR Chin Stacey M SM Musetti Bruno B Ledford Benjamin T BT Bahnson Edward M EM Stupp Samuel I SI Kibbe Melina R MR
Advanced healthcare materials 20190108 3
Nanomedicine is a promising, noninvasive approach to reduce atherosclerotic plaque burden. However, drug delivery is limited without the ability of nanocarriers to sense and respond to the diseased microenvironment. In this study, nanomaterials are developed from peptide amphiphiles (PAs) that respond to the increased levels of matrix metalloproteinases 2 and 9 (MMP2/9) or reactive oxygen species (ROS) found within the atherosclerotic niche. A pro-resolving therapeutic, Ac2-26, derived from anne ...[more]