Ontology highlight
ABSTRACT:
SUBMITTER: Lin TY
PROVIDER: S-EPMC6367351 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Lin Ting-Yu TY Abbassi Nour El Hana NEH Zakrzewski Karol K Chramiec-Głąbik Andrzej A Jemioła-Rzemińska Małgorzata M Różycki Jan J Glatt Sebastian S
Nature communications 20190207 1
The Elongator complex catalyzes posttranscriptional tRNA modifications by attaching carboxy-methyl (cm<sup>5</sup>) moieties to uridine bases located in the wobble position. The catalytic subunit Elp3 is highly conserved and harbors two individual subdomains, a radical S-adenosyl methionine (rSAM) and a lysine acetyltransferase (KAT) domain. The details of its modification reaction cycle and particularly the substrate specificity of its KAT domain remain elusive. Here, we present the co-crystal ...[more]