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How Elongator Acetylates tRNA Bases.

ABSTRACT: Elp3, the catalytic subunit of the eukaryotic Elongator complex, is a lysine acetyltransferase that acetylates the C5 position of wobble-base uridines (U34) in transfer RNAs (tRNAs). This Elongator-dependent RNA acetylation of anticodon bases affects the ribosomal translation elongation rates and directly links acetyl-CoA metabolism to both protein synthesis rates and the proteome integrity. Of note, several human diseases, including various cancers and neurodegenerative disorders, correlate with the dysregulation of Elongator's tRNA modification activity. In this review, we focus on recent findings regarding the structure of Elp3 and the role of acetyl-CoA during its unique modification reaction.

SUBMITTER: Abbassi NE

PROVIDER: S-EPMC7663514 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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How Elongator Acetylates tRNA Bases.

Abbassi Nour-El-Hana NE Biela Anna A Glatt Sebastian S Lin Ting-Yu TY

International journal of molecular sciences 20201103 21

Elp3, the catalytic subunit of the eukaryotic Elongator complex, is a lysine acetyltransferase that acetylates the C5 position of wobble-base uridines (U<sub>34</sub>) in transfer RNAs (tRNAs). This Elongator-dependent RNA acetylation of anticodon bases affects the ribosomal translation elongation rates and directly links acetyl-CoA metabolism to both protein synthesis rates and the proteome integrity. Of note, several human diseases, including various cancers and neurodegenerative disorders, co ...[more]

PMID: 33152999

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