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Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults.


ABSTRACT: It is unclear whether associations between total cholesterol (TC) levels and all-cause mortality and the optimal TC ranges for lowest mortality vary by sex and age. 12,815,006 Korean adults underwent routine health examinations during 2001-2004, and were followed until 2013. During follow-up, 694,423 individuals died. U-curve associations were found. In the TC ranges of 50-199 and 200-449?mg/dL, each 39?mg/dL (1?mmol/L) increase in TC was associated with 23% lower (95% CI:23%,24%) and 7% higher (6%,7%) mortality, respectively. In the age groups of 18-34, 35-44, 45-54, 55-64, 65-74, and 75-99 years, each 1?mmol/L higher TC increased mortality by 14%, 13%, 8%, 7%, 6%, and 3%, respectively (P?

SUBMITTER: Yi SW 

PROVIDER: S-EPMC6367420 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults.

Yi Sang-Wook SW   Yi Jee-Jeon JJ   Ohrr Heechoul H  

Scientific reports 20190207 1


It is unclear whether associations between total cholesterol (TC) levels and all-cause mortality and the optimal TC ranges for lowest mortality vary by sex and age. 12,815,006 Korean adults underwent routine health examinations during 2001-2004, and were followed until 2013. During follow-up, 694,423 individuals died. U-curve associations were found. In the TC ranges of 50-199 and 200-449 mg/dL, each 39 mg/dL (1 mmol/L) increase in TC was associated with 23% lower (95% CI:23%,24%) and 7% higher  ...[more]

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